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Innovative Products > HUCPVC Technologies
 
 
HUCPVCs are a type of stem cell – a “mesenchymal stromal cell” (MSC) – also called mesenchymal stem cell- cells which have many varied and special properties. MSCs give rise to specialized cells in the body that make the musculo-skeletal system (bone, cartilage, fibrous tissue and muscle). MSCs have also been shown to have very special immune-regulatory functions and have been used to treat immune and inflammatory diseases.
 
HUCPVCs = Human Umbilical Cord Perivascular Cells  
 
HUCPVCs, extracted from umbilical cord tissue, are the richest source of MSCs ever discovered. They can rapidly provide relevant doses required for stem cell therapy.
 
   The HUCPVC Advantage:
  • A rich source of non-controversial stem cells
  • Adult stem cells – not embryonic
  • Derived from cord tissue which is discarded at birth
  • Multipotential: shown to produce all five connective tissues - bone, cartilage, muscle, fibrous tissue and fat.
  • Shown in, in vitro tests, to have the same immuno-regulatory capacity as other MSCs
  • Fast proliferation, enabling rapid attainment of clinically-relevant numbers of cells
  • Can be easily frozen until required for use
 
HUCPVC Storage™
 
Focuses on the collection and cryogenic storage of the cells for a family, at the birth of their child. Cryogenic storage provides a stabilized environment for the cells to be kept in liquid nitrogen at a constant temperature of -196˚C, proven to maintain cell functionality after thaw for future clinical use. Available only through our licensees.
 
Where do HUCPVCs come from?
 
TRT discovered this special population of ethically non-controversial stem cells in the tissue immediately surrounding the blood vessels of the human umbilical cord. These are different from cells taken from the placenta or Wharton’s Jelly.
HUCPVCs are true multipotent mesenchymal stromal cells.

HUCPVCs are also quite distinct from the blood stem cells which circulate in the blood itself. Blood stem cells, taken from umbilical cord blood, have none of the unique properties of MSCs.
 
Clinical uses
 
MSCs are already being employed in clinical medicine to treat diseases such as Crohn’s disease, heart attack and bone diseases. MSCs are currently harvested from bone marrow, and the supply of cells from this source is limited. In comparison,the umbilical cord is much richer in these cells. MSC research also suggests that MSCs may be used to treat many other immune, inflammatory and degenerative diseases such as Rheumatoid Arthritis, Multiple Sclerosis, or liver conditions. Alternatively, they may be used together with blood stem cells to reconstitute a patient’s bone marrow. In addition, they can be used to regenerate the musculo-skeletal tissues of the body – bone, cartilage, muscle, ligaments and tendons.
 
Do HUCPVCs differ from Bone Marrow (BM)-derived MSCs?
 
HUCPVCs are a specialized source of MSCs found in the Umbilical Cord Tissue and stored until needed for therapy, whereas BM is taken directly from the patients own bone marrow. As the MSC number in BM is low, the cells have to be grown for several weeks before being ready for therapeutic use.
 
With HUCPVCs the source of cells is extracted from the umbilical cord after the full term birth of a new born baby, providing access to an extremely rich source of MSCs. HUCPVCs also grow very quickly – this translates into a shorter turnaround time for therapeutic doses of cells. Independent studies at Princess Margaret Hospital in Toronto, and at the National Institutes of Health in Bethesda, USA, have shown that HUCPVCs are bio-equivalent to bone marrow-derived MSCs.
 
As the umbilical cord is currently discarded as medical waste after the full term birth of a baby, storing this new source of stem cells makes sense as it does not compromise the health of either mother or baby.
 
 
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