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| Innovative Products >
HUCPVC Technologies |
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| HUCPVCs are a type of stem cell a mesenchymal stromal cell (MSC) also
called mesenchymal stem cell- cells which
have many varied and special properties. MSCs give rise
to specialized cells in the body that make the
musculo-skeletal system (bone, cartilage, fibrous tissue
and muscle). MSCs have also been shown to have very
special immune-regulatory functions and have been used
to treat immune and inflammatory
diseases. |
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HUCPVCs = Human Umbilical Cord
Perivascular Cells  |
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| HUCPVCs, extracted from umbilical cord
tissue, are the richest source of MSCs ever discovered.
They can rapidly provide relevant doses required for
stem cell therapy. |
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The HUCPVC
Advantage:
- A rich source of
non-controversial stem cells
- Adult stem cells not
embryonic
- Derived from cord tissue which is
discarded at birth
- Multipotential: shown to produce
all five connective tissues - bone, cartilage,
muscle, fibrous tissue and fat.
- Shown in, in vitro
tests, to have the same immuno-regulatory
capacity as other MSCs
- Fast proliferation, enabling
rapid attainment of clinically-relevant numbers
of cells
- Can be easily frozen until
required for use
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| Focuses on the collection and cryogenic
storage of the cells for a family, at the birth of their
child. Cryogenic storage provides a stabilized
environment for the cells to be kept in liquid nitrogen
at a constant temperature of -196C, proven to maintain
cell functionality after thaw for future clinical use.
Available only through our licensees. |
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TRT discovered this special population of
ethically non-controversial stem cells in the tissue
immediately surrounding the blood vessels of the human
umbilical cord. These are different from cells taken
from the placenta or Whartons Jelly.
HUCPVCs are true
multipotent mesenchymal stromal cells.
HUCPVCs
are also quite distinct from the blood stem cells which
circulate in the blood itself. Blood stem cells, taken
from umbilical cord blood, have none of the unique
properties of MSCs. |
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| MSCs are already being employed in
clinical medicine to treat diseases such as Crohns
disease, heart attack and bone diseases. MSCs are
currently harvested from bone marrow, and the supply of
cells from this source is limited. In comparison,the
umbilical cord is much richer in these cells. MSC
research also suggests that MSCs may be used to treat
many other immune, inflammatory and degenerative
diseases such as Rheumatoid Arthritis, Multiple
Sclerosis, or liver conditions. Alternatively, they may
be used together with blood stem cells to reconstitute a
patients bone marrow. In addition, they can be used to
regenerate the musculo-skeletal tissues of the body
bone, cartilage, muscle, ligaments and tendons. |
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| HUCPVCs are a specialized source of MSCs
found in the Umbilical Cord Tissue and stored until
needed for therapy, whereas BM is taken directly from
the patients own bone marrow. As the MSC number in BM is
low, the cells have to be grown for several weeks before
being ready for therapeutic use. |
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| With HUCPVCs the source of cells is
extracted from the umbilical cord after the full term
birth of a new born baby, providing access to an
extremely rich source of MSCs. HUCPVCs also grow very
quickly this translates into a shorter turnaround time
for therapeutic doses of cells. Independent studies at
Princess Margaret Hospital in Toronto, and at the National Institutes of Health in
Bethesda, USA, have shown that HUCPVCs are
bio-equivalent to bone marrow-derived MSCs. |
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| As the umbilical cord is currently
discarded as medical waste after the full term birth of
a baby, storing this new source of stem cells makes
sense as it does not compromise the health of either
mother or baby. |
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