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| Innovative
Products> OsteoScaf |
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| OsteoScaf is a
bone substitute, or scaffold, which helps
initiate the healing of bone defects and broken
bones. It can be used alone, or as a delivery
vehicle for bone healing cells. |
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| This scaffold is a product of
almost 10 years of research in both materials
and biological design.
OsteoScaf is a unique, fully
resorbable 3-phase biomaterial which is used as
a substitute for trabecular bone grafts. No
other scaffold technology on the market
approaches the interconnecting macroporosity of
OsteoScaf. |
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| OsteoScaf is
osteoconductive, anti-inflammatory, mechanically
strong and can be combined with bone healing
cells to further aid tissue repair. These
characteristics make the
OsteoScaf system unique in the fields
of biomaterials and tissue
engineering. |
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| The mechanical integrity of
OsteoScaf is vitally important
for two reasons. First, it enables easy handling
at the time of surgery. Second, it maintains its
architecture after cell seeding and the invasion
of host healing tissue. |
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| To date there is no equivalent
polymer-based system that possesses all of the
characteristics of our current
OsteoScaf scaffold formulation
thereby making this scaffold technology an
important addition to the field. |
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| The macroporous open architecture
of OsteoScaf is a fundamental
design criterion. Biological repair can be
enhanced with the use of materials designed
specifically to provide an optimal surface for
host tissue interaction. With an open pore
structure to enable rapid tissue ingrowth at the
wound site, OsteoScaf proves
useful in repairing bone. |
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| In keeping with our design
criteria of fabricating a completely resorbable
construct, we have demonstrated each of the
three component phases of the scaffold to be
biodegradable [The polymer degrades by
hydrolysis while the two calcium phosphate
phases are resorbed by osteoclasts, the cells
which resorb bone]. This is not possible in
competitive systems where dense ceramic
hydroxyapatite or bioactive glass particles are
included. |
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| Whilst many groups have reported
that thin calcium phosphate coatings can
accelerate osseous healing, these findings have
either used metallic substrates such as titanium
and tantalum or polymeric substrates in
vitro. |
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| To date we are the only group
describing the in-vivo performance of
thin film CaP coated polymeric composites. We
provide the only evidence of a successful
biodegradable, polymeric based system for use in
bone engineering applications. |
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| No adverse inflammatory response
is recorded with the use of
OsteoScaf. A widely appreciated
phenomena pertaining to in vivo
performance of polyester based materials is the
propensity for generation of a chronic
inflammatory response. With our surface coating
of CaP on OsteoScaf we have
completely eradicated a chronic inflammatory
response. |
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| Human
Trabecular
Bone | |
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| OsteoScaf
I | |
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| OsteoScaf II
with thin surface coating of CaP Coating has
been fractured to demonstrate thickness of layer
~ 3mm. This coating renders the scaffold
osteoconductive, without having an effect on the
macroporosity. | | |
